Apelin affects the mouse aging urinary peptidome with minimal effects on kidney
作者: Claire VinelJoost P. SchanstraFranck BoizardOphélie PéreiraJohanna AuriauAlizée DortignacBenjamin BreuilGuylène FeuilletEsther Nkuipou-KenfackPetra ZürbigPhilippe ValetJean-Loup BascandsCédric DrayColette Denis
刊名: Scientific Reports, 2019, Vol.9 (1), pp.1-12
来源数据库: Directory of Open Access Journals
DOI: 10.1038/s41598-019-47109-4
原始语种摘要: Abstract Kidney function is altered by age together with a declined filtration capacity of 5–10% per decade after 35 years. Renal aging shares many characteristics with chronic kidney disease. Plasma levels of the bioactive peptide apelin also decline with age and apelin has been shown to be protective in chronic kidney disease. Therefore we evaluated whether apelin could also improve aging-induced renal lesions and function in mice. Since urine is for the major part composed of proteins and peptides originating from the kidney, we first studied apelin-induced changes, in the aging urinary peptidome. Despite the recently published age-associated plasma decrease of apelin, expression of the peptide and its receptor was increased in the kidneys of 24 months old mice. Twenty-eight days...
全文获取路径: DOAJ  (合作)
影响因子:2.927 (2012)

  • aging 老化
  • urinary 尿的
  • mouse 小鼠
  • kidney 肾脏
  • organs 男生殖器
  • together 共同
  • modifying 修改
  • although 虽然
  • effects 海员自身物品
  • staining 染色