Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy
作者: Chen XTong HChen YChen CYe JMo QZhao GHong GZheng CLu Z
刊名: OncoTargets and Therapy, 2018, Vol.Volume 11 , pp.867-881
来源数据库: Directory of Open Access Journals
关键词: Acute kidney injuryAutophagyKlothoSeptic AKI
原始语种摘要: Xinxin Chen,1 Huan Tong,2 Yu Chen,3 Chaosheng Chen,1 Jingjing Ye,2 Qingfei Mo,2 Guangju Zhao,2 Guangliang Hong,2 Chenfei Zheng,1 Zhongqiu Lu2 1Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; 2Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; 3Department of Nephrology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated with Zhejiang Chinese Medical University, Wenzhou, Zhejiang, China Background: The role of Klotho (KL) in sepsis-induced acute kidney injury (AKI) and the potential relationship between KL and autophagy in septic AKI were investigated. Materials and methods: A murine model of sepsis-induced AKI was established by cecal ligation and puncture...
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影响因子:2.073 (2012)

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关键词翻译
关键词翻译
  • autophagy 自体消瘦
  • induced 感应的
  • sepsis 败血症
  • renal 肾的
  • LPS Laboratory Peripheral System
  • stimulator 刺激质
  • septic 腐败的
  • significantly 较大地
  • apoptosis 细胞死
  • CLP Communication Line Processor