The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer.
作者: Eleftherios P SamartzisAurelia NoskeAlexander MeiselZsuzsanna VargaDaniel FinkPatrick Imesch
刊名: PLoS ONE, 2017, Vol.9 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0083296
原始语种摘要: INTRODUCTION: The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates proliferative effects induced by estrogen but also by tamoxifen. The aim of our study was to analyze the frequency of GPER in a large collective of primary invasive breast carcinomas, with special emphasis on the subcellular expression and to evaluate the association with clinicopathological parameters and patient overall survival. METHODS: The tissue microarrays from formalin-fixed, paraffin embedded samples of primary invasive breast carcinomas (n = 981) were analyzed for GPER expression using immunohistochemistry. Expression data were compared to the clinicopathological parameters and overall survival. GPER localization was also analyzed in two immortalized breast cancer cell lines...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • distinct 相异的
  • expression 表示
  • breast 胸部
  • expressed 榨出的
  • cytoplasmic 细胞质的
  • subcellular 亚细胞的
  • estrogen 雌激素
  • coupled 耦合
  • observed 观察到的
  • receptor 接受体