EGCG overcomes gefitinib resistance by inhibiting autophagy and augmenting cell death through targeting ERK phosphorylation in NSCLC
作者: Meng JChang CChen YBi FJi CLiu W
刊名: OncoTargets and Therapy, 2019, Vol.Volume 12 , pp.6033-6043
来源数据库: Directory of Open Access Journals
关键词: EGCGGefitinib resistanceNSCLCAutophagyERK.
原始语种摘要: Jiao Meng,1,2,* Cuicui Chang,1,* Yuhua Chen,1,2 Fangfang Bi,1,2 Chen Ji,1 Wei Liu21Central Laboratory of Medicine School, Xi’an Peihua University, Xi’an 710100, People’s Republic of China; 2Department of Medical Science Research Center, Shaanxi Fourth People’s Hospital, Xi’an 710143, People’s Republic of China*These authors contributed equally to this workBackground: Several EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib (Gef), have been used as effective clinical therapies for patients with non-small cell lung cancer (NSCLC). However, due to acquired resistance, the efficacy of Gef treatment is severely blocked. Our preliminary study found that epigallocatechin gallate (EGCG) in combination with Gef could work synergistically to increase the sensitivity to Gef in NSCLC, but...
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影响因子:2.073 (2012)

  • 耐久的 协同的
  • autophagy 自体消瘦
  • targeting 导向目标
  • augmenting 增强
  • inhibiting 抑制
  • combined 组合
  • death 
  • synergism 协同酌
  • synergistic 协同的
  • resistant 协同的
  • combination 聚形