3β-hydroxysterol δ24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy.
作者: Makoto SaitoTakashi TakanoTomohiro NishimuraMichinori KoharaKyoko Tsukiyama-Kohara
刊名: PLoS ONE, 2017, Vol.10 (4)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0124197
原始语种摘要: In our previous study, we demonstrated that 3β-hydroxysterol Δ24-reductase (DHCR24) was overexpressed in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), and that its expression was induced by HCV. Using a monoclonal antibody against DHCR24 (2-152a MAb), we found that DHCR24 was specifically expressed on the surface of HCC cell lines. Based on these findings, we aimed to establish a novel targeting strategy using 2-152a MAb to treat HCV-related HCC. In the present study, we examined the antitumor activity of 2-152a MAb. In the presence of complement, HCC-derived HuH-7 cells were killed by treatment with 2-152a MAb, which was mediated by complement-dependent cytotoxicity (CDC). In addition, the antigen recognition domain of 2-152a MAb was responsible for the unique anti-HCV...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • hepatocellular 肝细胞性的
  • targeting 导向目标
  • hepatitis 肝炎
  • reductase 还原酶
  • cells 麻风细胞
  • antibody 抗体
  • carcinoma 癌症
  • cytotoxic 细胞毒素的
  • demonstrated 探明的储量
  • monoclonal 单细胞系的