Methylglyoxal (MG) and Cerebro-Renal Interaction: Does Long-Term Orally Administered MG Cause Cognitive Impairment in Normal Sprague-Dawley Rats?
甲基乙二醛( MG )和脑-肾相互作用:长期口服MG是否引起正常Sprague-Dawley大鼠的认知障碍?
作者: Kimio WatanabeKana OkadaRyoji FukaboriYoshimitsu HayashiKoichi AsahiHiroyuki TerawakiKazuto KobayashiTsuyoshi WatanabeMasaaki Nakayama
作者单位: 1epartment of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan
2Graduate School of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan
3Department of Molecular Genetics, Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan
4Department of Nephrology, Hypertension, Diabetology,
刊名: Toxins, 2014, Vol.6 (1), pp.254-269
来源数据库: Directory of Open Access Journals
DOI: 10.3390/toxins6010254
关键词: Cerebro-renal interactionMethylglyoxalCognitive impairmentChronic kidney disease
原始语种摘要: Methylglyoxal (MG), one of the uremic toxins, is a highly reactive alpha-dicarbonyl compound. Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma MG levels and presence of kidney dysfunction. Therefore, the present study aims to examine whether MG is a direct causative substance for CI development. Eight-week-old male Sprague-Dawley (SD) rats were divided into two groups: control (n = 9) and MG group (n = 10; 0.5% MG in drinking water), and fed a normal diet for 12 months. Cognitive function was evaluated by two behavioral tests (object exploration test and radial-arm maze test) in early (4–6 months of age) and late phase (7–12 months of age). Serum MG was significantly elevated in the MG group (495.8 ± 38.1 vs. 244.8 ± 28.2 nM; p <...
全文获取路径: DOAJ  (合作)
影响因子:2.129 (2012)

  • system 
  • control 控制
  • function 函数
  • development 开发
  • impairment 减损
  • group 
  • MG Main Generator
  • administration 管理
  • between 在中间
  • uremic 尿毒症的