Chitosan Improves Anti-Biofilm Efficacy of Gentamicin through Facilitating Antibiotic Penetration
作者: Haibo MuFan GuoHong NiuQianjin LiuShunchun WangJinyou Duan
作者单位: 1ollege of Science, Northwest A&F University, Yangling 712100, China
2College of Science, Northwest A&F University, Yangling 712100, China
3The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China
4College of Science
刊名: International Journal of Molecular Sciences, 2014, Vol.15 (12), pp.22296-22308
来源数据库: Directory of Open Access Journals
DOI: 10.3390/ijms151222296
关键词: ChitosanAntibioticBiofilmsPenetration
原始语种摘要: Antibiotic overuse is one of the major drivers in the generation of antibiotic resistant “super bugs” that can potentially cause serious effects on health. In this study, we reported that the polycationic polysaccharide, chitosan could improve the efficacy of a given antibiotic (gentamicin) to combat bacterial biofilms, the universal lifestyle of microbes in the world. Short- or long-term treatment with the mixture of chitosan and gentamicin resulted in the dispersal of Listeria monocytogenes (L. monocytogenes) biofilms. In this combination, chitosan with a moderate molecular mass (~13 kDa) and high N-deacetylation degree (~88% DD) elicited an optimal anti-biofilm and bactericidal activity. Mechanistic insights indicated that chitosan facilitated the entry of gentamicin into the...
全文获取路径: DOAJ  (合作)
影响因子:2.464 (2012)

  • 认真的 生物薄膜
  • gentamicin 艮他霉素
  • chitosan 壳聚糖
  • antibiotic 抗生素
  • recommended 推荐
  • potentially 可能地
  • overcome 克服
  • resistant 耐久的
  • microbes 微生物
  • biofilm 生物薄膜
  • serious 生物薄膜