The contributory role of angiotensin receptor-like 1 gene multiple polymorphisms in hypertension among northeastern Han Chinese.
作者: Ruoshan LiuHongye ZhaoYuefei WangYanli WangChangzhu LuYu XiaoNan JiaBin WangWenquan Niu
刊名: PLoS ONE, 2017, Vol.9 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0086095
原始语种摘要: BACKGROUND AND OBJECTIVE: Via direct sequencing, we have recently identified six common polymorphisms in angiotensin receptor-like 1 (AGTRL1) gene, and found only two polymorphisms were significantly associated with hypertension in a family-based analysis on 1,015 southern Han Chinese. Extending our previous work and considering the ubiquity of epistasis in determining disease susceptibility, we, in this study, sought to explore the potential interaction of AGTRL1 gene six polymorphisms with hypertension in a large northeastern Han Chinese population. METHODS AND RESULTS: This was a case-control study involving 1,009 sporadic hypertensive patients and 756 normotensive controls. Data were analyzed by Haplo.Stats and multifactor dimensionality reduction (MDR) softwares. There were no...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • hypertension 高血压
  • angiotensin 血管紧张肽
  • normotensive 血压正常的
  • hypertensive 高血压的
  • northeastern 来自东北的
  • independently 独立地
  • triglyceride 甘油三酯
  • controls 控制机构
  • cholesterol 胆甾醇
  • receptor 接受体