Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3
作者: Cheng-Shi HeYi-Cheng LiuZhi-Peng XuPeng-Chen DaiXiao-Wei ChenDe-Hai Jin
刊名: Cellular Physiology and Biochemistry, 2016, Vol.40 (5), pp.1221-1229
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000453175
关键词: ChemoresistanceAstragaloside IVB7-H3Non-small cell lung cancer
原始语种摘要: Background: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus, has been reported to exhibit anti-inflammation, anti-cancer and immunoregulatory properties. In the present study, we investigated the role of astragaloside IV in the chemoresistance to cisplatin in NSCLC cells. Methods: We established astragaloside IV-suppressed NSCLC cell lines including A549, HCC827, and NCI-H1299 and evaluated their sensitivity to cisplatin in vitro. In addition, we examined the mRNA and protein levels of B7-H3 in response to cisplatin-based chemotherapy. Results: We showed that high doses of astragaloside IV (10, 20, 40 ng/ml) inhibited NSCLC cell growth, whereas low concentrations of...
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关键词翻译
关键词翻译
  • cisplatin 顺氯氨铂
  • chemotherapy 化学疗法
  • Cancer 巨蟹座
  • combined 组合
  • significantly 较大地
  • protein 蛋白质
  • therapeutic 治疗的
  • cancer 癌症
  • mRNA m核糖核酸
  • treatment 处理