Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis.
作者: Mingliang GuXiaoqun DongXuezhi ZhangXumin WangYue QiJun YuWenquan Niu
刊名: PLoS ONE, 2017, Vol.7 (6)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0037970
原始语种摘要: BACKGROUND: The association between polymorphisms on 15q25.1 and lung cancer has been widely evaluated; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two polymorphisms (CHRNA3 gene: rs1051730 and AGPHD1 gene: rs8034191) on 15q25.1. METHODS: Data were extracted from 15 and 14 studies on polymorphisms rs1051730 and rs8034191 involving 12301/14000 and 14075/12873 lung cancer cases/controls, respectively. The random-effects model was applied, addressing heterogeneity and publication bias. RESULTS: The two polymorphisms followed Hardy-Weinberg equilibrium for all studies (P>0.05). For rs1051730-G/A, carriers of A allele had a 36% increased risk for lung cancer (95% confidence interval [CI]:...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • heterogeneity 不均匀性
  • association 联合
  • cancer 癌症
  • allelic 等位的
  • allele 等位基因
  • between 在中间
  • analysis 分析
  • contradictory 矛盾
  • publication 公布
  • comprehensive 全面