Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats
作者: Nadia Artha DewiAulanni'am Aulanni’amHidayat SujutiMuhammad Aris WidodoDjoko Wahono Soeatmadji
作者单位: 1Department of Ophthalmology, Vitreoretinal Subdivision, Faculty of Medicine, Brawijaya University, Malang 65111, Indonesia
2Department of Biochemistry, Faculty of Sciences, Brawijaya University, Malang 65111, Indonesia
3Department of Biochemistry, Faculty of Medicine, Brawijaya University, Malang 65111, Indonesia
4Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang 65111, Indonesia
5Department of Endocrinology, Faculty of Medicine, Brawijaya University, Malang 65111, Indonesia
刊名: International Journal of Ophthalmology, 2018, Vol.11 (3), pp.375-381
来源数据库: Directory of Open Access Journals
DOI: 10.18240/ijo.2018.03.05
关键词: 381PericyteAngiopoietin/Tie-2DiabetesCell migrationRat
原始语种摘要: AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor, and DMSO intravitreal. Retinal digest preparation was done to examine the retinal vasculature including pericyte: endothelial ratio, and morphology of pericyte migration. Tie-2, ERK1/2 and Akt/PKB phosporylation were analyzed by confocal laser scanning microscopy. RESULTS: There was a correlation between pericyte migration with increasing Ang-2 (P<0.05). Pericyte number reduced by 40% (1:2.4) after 5wk diabetes on diabetic rats. The pericyte: endothelial ratio on group with Tie-2 inhibitor were 1:1.8. The same result shows on group with...
全文获取路径: DOAJ  (合作)
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影响因子:0.119 (2012)

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关键词翻译
关键词翻译
  • pericyte 周皮细胞
  • retinal 视黄醛
  • diabetic 糖尿病患者
  • migration 迁移
  • signaling 发信号
  • pathway 轨道
  • inhibitor 抑制剂
  • through 经过
  • receptor 接受体
  • inhibition 抑制