Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery.
作者: Daisuke NishizawaMakoto NagashimaRyoji KatohYasuo SatohMegumi TagamiShinya KasaiYasukazu OgaiWenhua HanJunko HasegawaNaohito ShimoyamaIchiro SoraMasakazu HayashidaKazutaka Ikeda
刊名: PLoS ONE, 2017, Vol.4 (9)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0007060
原始语种摘要: Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) channel subunit, GIRK2, that is an important molecule in opioid transmission. In our initial polymorphism search, a total of nine single-nucleotide polymorphisms (SNPs) were identified in the whole exon, 5'-flanking, and exon-intron boundary regions of the KCNJ6 gene encoding GIRK2. Among them, G-1250A and A1032G were selected as representative SNPs for further association studies. In an association study of 129 subjects who underwent major open abdominal surgery, the A/A genotype in the A1032G SNP and -1250G/1032A...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • analgesic 镇痛药
  • postoperative 手术后的
  • abdominal 腹部的
  • opioid 鸦片样物质
  • morphine 吗啡
  • major 知的
  • haplotype 单倍体型
  • predict 预见
  • increased 增加
  • potassium