Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3.
作者: Toru KobayashiKazuo WashiyamaKazutaka Ikeda
刊名: PLoS ONE, 2017, Vol.4 (7)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0006311
原始语种摘要: BACKGROUND: Neurosteroids have various physiological and neuropsychopharmacological effects. In addition to the genomic effects of steroids, some neurosteroids modulate several neurotransmitter receptors and channels, such as N-methyl-D-aspartate receptors, gamma-aminobutyric acid type A (GABA(A)) receptors, and sigma(1) receptors, and voltage-gated Ca(2+) and K(+) channels. However, the molecular mechanisms underlying the various effects of neurosteroids have not yet been sufficiently clarified. In the nervous system, inwardly rectifying K(+) (Kir) channels also play important roles in the control of resting membrane potential, cellular excitability and K(+) homeostasis. Among constitutively active Kir2 channels in a major Kir subfamily, Kir2.3 channels are expressed predominantly in the...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • sulfate 硫酸盐
  • rectifying 精馏
  • potentiation 增强
  • inwardly 在内部
  • pregnenolone 孕烯醇酮
  • micromolar 微摩尔的
  • extracellular 胞外的
  • concentration 浓度
  • forebrain 前脑
  • heteromeric 异数