Lipopolysaccharide accelerates fine particulate matter-induced cell apoptosis in human lung bronchial epithelial cells
作者: Qin RuQi XiongLin ChenXiang TianKai YueBaomiao MaLu LiuRihui WuCongyue XuMingshan PiChaoying Li
作者单位: 1ianghan University, Wuhan, China(Wuhan Institutes of Biomedical Sciences)
2Jianghan University, Wuhan, China(Wuhan Institutes of Biomedical Sciences)
3Jianghan University, Wuhan, China(Wuhan Institutes of Bio
刊名: International Journal of Occupational Medicine and Environmental Health, 2018, Vol.31 (2), pp.173-183
来源数据库: Directory of Open Access Journals
DOI: 10.13075/ijomeh.1896.00527
关键词: ApoptosisCytotoxicityInflammationFine particulate matterFree radicalsBronchial epithelial cells
原始语种摘要: ObjectivesThe aim of the study has been to investigate the effect of the Standard Reference Material of fine particulatematter (SRM 2786) on cytotoxicity and apoptosis in human lung bronchial epithelial cells (16HBE cells). Whether thelipopolysaccharide (LPS)-induced inflammation could further accelerate cell apoptosis induced by SRM 2786 stimulationhas also been determined.Material and Methods16HBE cells were exposed to various doses of SRM 2786 with orwithout LPS. The following parameters: cytotoxicity, apoptotic rate, Bax/Bcl-2 expression, nitric oxide (NO) production,and reactive oxygen species (ROS) generation were measured.ResultsThe results have shown that SRM 2786 inducescell damage and apoptosis of 16HBE cells as demonstrated by significant decrease in expression of Bcl-2 and...
全文获取路径: PDF下载  DOAJ  (合作)
分享到:

×
关键词翻译
关键词翻译
  • bronchial 支气管的
  • epithelial 上皮的
  • cells 麻风细胞
  • induced 感应的
  • apoptosis 细胞死
  • inflammation 炎症
  • increased 增加
  • particulate 粒子
  • SRM Short Range Modem
  • LPS Laboratory Peripheral System