A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi.
作者: Jean Henrique da Silva RodriguesTânia Ueda-NakamuraArlene Gonçalves CorrêaDiego Pereira SangiCelso Vataru Nakamura
刊名: PLoS ONE, 2018, Vol.9 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0085706
原始语种摘要: Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi that affects millions of people, mainly in Latin America where it is considered endemic. The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, benznidazole, which unfortunately induces several side effects and it is not successful in the cure of most of the chronic patients. In order to improve the drug armamentarium against Chagas' disease, in the present study we describe the synthesis of the compound 3-chloro-7-methoxy-2-(methylsulfonyl) quinoxaline (quinoxaline 4) and its activity, alone or in combination with benznidazole, against Trypanosoma cruzi in vitro.Quinoxaline 4 was found to be strongly active against Trypanosoma cruzi Y strain and more...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • against 反对
  • quinoxaline 喹恶啉
  • alone 单独地
  • combination 聚形
  • potent 强大的
  • parasite 寄生物
  • induced 感应的
  • methylsulfonyl 甲磺酸
  • chemotherapy 化学疗法
  • armamentarium 一套设备