Over-expression of mitochondrial antiviral signaling protein inhibits coxsackievirus B3 infection by enhancing type-I interferons production
作者: Zhang Qing-MengSong Wu-QiLi Yu-JunQian JunZhai Ai-XiaWu JingLi Ai-MeiHe Jun-MingZhao Jin-YunYu XinWei Lan-LanZhang Feng-Min
刊名: Virology Journal, 2012, Vol.9 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1186/1743-422X-9-312
关键词: Mitochondrial antiviral signaling proteinCoxsackievirus B3InterferonAntiviral response
原始语种摘要: Abstract Background Recent studies have revealed that Mitochondrial Antiviral Signaling (MAVS) protein plays an essential role in the inhibition of viral infection through type I interferon (IFN) pathway. It has been shown that 3C (pro) cysteine protease of coxsackievirus B3 (CVB3) cleaves MAVS to inhibit type I IFNs induction. Other workers also found that MAVS knock-out mice suffered CVB3 susceptibility and severe histopathological change. Accordingly,our experiments were designed to explore the protection of over-expressing MAVS against CVB3 infection and the possible mechanism. Results In this study, HeLa cells (transfected with MAVS constructs pre- or post- exposure to CVB3) were used to analyze the function of exogenous MAVS on CVB3 infection. The results revealed that though CVB3...
全文获取路径: DOAJ  (合作)
影响因子:2.092 (2012)

  • coxsackievirus 考克塞基病毒
  • interferons 干扰素
  • infection 感染
  • protein 蛋白质
  • antiviral 抗病毒的
  • enhancing 增强
  • effectively 有效地
  • signaling 发信号
  • exogenous 外源的
  • production 生产