Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ
作者: Pingping XiaYundan PanFan ZhangNa WangE WangQulian GuoZhi Ye
刊名: Cellular Physiology and Biochemistry, 2018, Vol.45 (6), pp.2351-2368
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000488183
关键词: PioglitazoneCerebral ischemiaPyroptosisPPAR-γHMGB-1/RAGERac1
原始语种摘要: Background/Aims: Recent researches highlighted the protective potential of pioglitazone, a PPAR-γ agonist, in the progression of cerebral ischemia-reperfusion injury. However, there has been no study on the application of pioglitazone in treating ischemic stroke through mechanisms involving pyroptosis. Methods: The cerebral injury was established by middle cerebral artery occlusion (MCAO). in vitro ischemia in primary cultured astrocytes was induced by the oxygen-glucose deprivation (OGD). ELISA and Western Blot analysis were employed to the levels of PPAR-γ, pyroptosis-related biomarkers and cytoplasmic translocation of HMGB-1 and RAGE expression as well as Rac1 activity, respectively. Results: We demonstrated that repeated intraperitoneal administration of pioglitazone remarkably...
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  • cytoplasmic 细胞质的
  • expression 表示
  • knockdown 击倒
  • related 有关的
  • demonstrated 探明的储量
  • repeated 重复的
  • remarkably 显著地
  • translocation 移位
  • induced 感应的
  • occlusion 锢囚