The HMGB1/RAGE Pro-Inflammatory Axis in the Human Placenta: Modulating Effect of Low Molecular Weight Heparin
作者: Cristian ZenerinoAnna Maria NuzzoDomenica GiuffridaMarilisa BiolcatiAlessandra ZicariTullia TodrosAlessandro Rolfo
作者单位: 1epartment of Surgical Sciences, University of Turin, 10126 Turin, Italy
2Department of Surgical Sciences, University of Turin, 10126 Turin, Italy
3Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy
4Department of Surgical Sciences, University of Turin, 1012
刊名: Molecules, 2017, Vol.22 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules22111997
关键词: HeparinHMGB1PlacentaPre-eclampsiaReceptor for advanced glycation end products (RAGE)
原始语种摘要: We evaluated whether physiological and pre-eclamptic (PE) placentae, characterized by exacerbated inflammation, presented alterations in pro-inflammatory High Mobility Group Box 1 (HMGB1) and its Receptor of Advanced Glycation End products (RAGE) expression. Moreover, we investigated, in physiological placental tissue, the ability of Low Molecular Weight Heparin (LMWH) to modify HMGB1 structural conformation thus inhibiting RAGE binding and HMGB1/RAGE axis inflammatory activity. HMGB1, RAGE, IL-6 and TNFα (HMGB1/RAGE targets) mRNA expression were assessed by Real Time PCR. HMGB1, RAGE protein levels were assessed by western blot assay. Physiological term placental explants were treated by 0.5 U LMWH for 24 or 48 h. HMGB1 and RAGE expression and association were evaluated in LMWH explants...
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • expression 表示
  • relative 相对的
  • formation 建造
  • increased 增加
  • physiological 生理的
  • eclampsia 惊厥
  • inflammatory 激怒的
  • trophoblast 滋养层
  • placental 胎盘的
  • products 制品