The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model
作者: Nenad StojiljkovicSonja IlicVladimir JakovljevicNikola StojanovicSlavica StojnevHristina KocicMarko StojanovicGordana Kocic
作者单位: 1epartment of Physiology, Faculty of Medicine, University of Niš, Bulevar Zorana Ðinđića 81, 18000 Niš, Serbia
2Department of Physiology, Faculty of Medicine, University of Niš, Bulevar Zorana Ðinđića 81, 18000 Niš, Serbia
3Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
4Faculty of Medicine, University of Niš, Bulevar Zorana Ðinđića 81, 18000 Niš, Serbia
5Department of Pathology, Faculty of Medicine, University of Niš, Bulevar
刊名: Oxidative Medicine and Cellular Longevity, 2018, Vol.2018
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2018/2627917
原始语种摘要: Methotrexate is an antimetabolic drug with a myriad of serious side effects including nephrotoxicity, which presumably occurs due to oxidative tissue damage. Here, we evaluated the potential protective effect of lycopene, a potent antioxidant carotenoid, given in two different pharmaceutical forms in methotrexate-induced kidney damage in rats. Serum biochemical (urea and creatinine) and tissue oxidative damage markers and histopathological kidney changes were evaluated after systemic administration of both lycopene dissolved in corn oil and lycopene encapsulated in nanoliposomes. Similar to previous studies, single dose of methotrexate induced severe functional and morphological alterations of kidneys with cell desquamation, tubular vacuolation, and focal necrosis, which were followed by...
全文获取路径: DOAJ  (合作)
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影响因子:3.393 (2012)

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关键词翻译
关键词翻译
  • methotrexate 氨甲喋呤
  • lycopene 番茄烯
  • desquamation 剥离酌
  • creatinine 肌酸酐
  • oxidative 氧化的
  • nephrotoxicity 中毒性肾损害
  • induced 感应的
  • Encapsulation 封闭、灌封
  • Kidney 
  • encapsulated 压缩