Application of stem cell-derived retinal pigmented epithelium in retinal degenerative diseases: present and future
作者: Mingyue LuoYouxin Chen
作者单位: 1Department of Ophthalmology, Peking Union Medical College Hospital, Beijing 100730, China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
刊名: International Journal of Ophthalmology, 2018, Vol.11 (1), pp.150-159
来源数据库: Directory of Open Access Journals
DOI: 10.18240/ijo.2018.01.23
关键词: 159Retinal pigmented epithelium transplantationStem cellHuman embryonic stem cellInduced pluripotent stem cell
原始语种摘要: As a constituent of blood-retinal barrier and retinal outer segment (ROS) scavenger, retinal pigmented epithelium (RPE) is fundamental to normal function of retina. Malfunctioning of RPE contributes to the onset and advance of retinal degenerative diseases. Up to date, RPE replacement therapy is the only possible method to completely reverse retinal degeneration. Transplantation of human RPE stem cell-derived RPE (hRPESC-RPE) has shown some good results in animal models. With promising results in terms of safety and visual improvement, human embryonic stem cell-derived RPE (hESC-RPE) can be expected in clinical settings in the near future. Despite twists and turns, induced pluripotent stem cell-derived RPE (iPSC-RPE) is now being intensely investigated to overcome genetic and epigenetic...
全文获取路径: DOAJ  (合作)
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影响因子:0.119 (2012)

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关键词翻译
关键词翻译
  • retinal 视黄醛
  • epithelium 上皮
  • degenerative 退化的
  • derived 导生的
  • pluripotent 多能的
  • future 将来
  • pigmented 着色的
  • epigenetic 后成的
  • present 出席的
  • immunogenicity 致免疫性