Computational prediction of immunodominant antigenic regions & potential protective epitopes for dengue vaccination
作者: Karthikeyan MuthusamyKrishnasamy GopinathDharmalingam Nandhini
刊名: Indian Journal of Medical Research, 2016, Vol.144 (4), pp.587-591
来源数据库: Directory of Open Access Journals
DOI: 10.4103/0971-5916.200894
关键词: Antigenic region - dengue infection - epitope-based vaccine - sequence analysis
原始语种摘要: Background & objectives: Epitope-based vaccines (EVs) are specific, safe and easy to produce. However, vaccine failure has been frequently reported due to variation within epitopic regions. Therefore, development of vaccines based on conserved epitopes may prevent such vaccine failure. This study was undertaken to identify highly conserved antigenic regions in the four dengue serotypes to produce an epitope-based dengue vaccine.Methods: Polyprotein sequences of all four dengue serotypes were collected and aligned using MAFFT multiple sequence alignment plugin with Geneious Pro v6.1. Consensus sequences of the polyproteins for all four dengue serotypes were designed and screened against experimentally proven epitopes to predict potential antigenic regions that are conserved among all four...
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影响因子:2.061 (2012)

  • antigenic 抗原的
  • dengue 登革热
  • vaccination 注射疫苗
  • potential 
  • vaccines 疫苗
  • epitope 抗原决定部位
  • against 反对
  • protective 保护的
  • region 地域
  • screened 筛过的