Improved Hepatoprotective Effect of Liposome-Encapsulated Astaxanthin in Lipopolysaccharide-Induced Acute Hepatotoxicity
作者: Chun-Hung ChiuChun-Chao ChangShiang-Ting LinCharng-Cherng ChyauRobert Y. Peng
作者单位: 1Research Institute of Biotechnology, Hungkuang University, Taichung City 43302, Taiwan
2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan
刊名: International Journal of Molecular Sciences, 2016, Vol.17 (7)
来源数据库: Directory of Open Access Journals
DOI: 10.3390/ijms17071128
关键词: AstaxanthinLiposome encapsulationAntioxidant enzymesInflammationHepatotoxicity
原始语种摘要: Lipopolysaccharide (LPS)-induced acute hepatotoxicity is significantly associated with oxidative stress. Astaxanthin (AST), a xanthophyll carotenoid, is well known for its potent antioxidant capacity. However, its drawbacks of poor aqueous solubility and low bioavailability have limited its utility. Liposome encapsulation is considered as an effective alternative use for the improvement of bioavailability of the hydrophobic compound. We hypothesized that AST encapsulated within liposomes (LA) apparently shows improved stability and transportability compared to that of free AST. To investigate whether LA administration can efficiently prevent the LPS-induced acute hepatotoxicity, male Sprague-Dawley rats (n = six per group) were orally administered liposome-encapsulated AST at 2, 5 or 10...
全文获取路径: DOAJ  (合作)
影响因子:2.464 (2012)

  • hepatotoxicity 肝毒性
  • oxaloacetic 草酰乙酸(物)的
  • induced 感应的
  • transaminase 转氨酶
  • acetylcysteine 乙酰半胱胺酸
  • AST Add-Subtract Time
  • LPS Laboratory Peripheral System
  • encapsulated 压缩
  • significantly 较大地
  • xanthophyll 叶黄素