p66Shc Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain
作者: Hernán PérezPaola Vanesa FinocchiettoYael AlippeInés RebagliatiMaría Eugenia ElgueroNerina VillalbaJuan José PoderosoMaría Cecilia Carreras
作者单位: 1aboratory of Oxygen Metabolism, INIGEM-UBA-CONICET, Buenos Aires, Argentina
2Laboratory of Oxygen Metabolism, INIGEM-UBA-CONICET, Buenos Aires, Argentina
3Laboratory of Oxygen Metabolism, INIGEM-UBA-C
刊名: Oxidative Medicine and Cellular Longevity, 2018, Vol.2018
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2018/8561892
原始语种摘要: Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66Shc adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis by providing oxidative stress resistance and promoting longevity. p66Shc(−/−) mice are a unique opportunity to further comprehend the bidirectional relationship between redox homeostasis and the imbalance of mitochondrial biogenesis and dynamics during aging. This study shows that brain mitochondria of p66Shc(−/−) aged mice exhibit a reduced alteration of redox balance with a decrease in both ROS generation and its detoxification activity. We also demonstrate a strong link between reactive...
全文获取路径: DOAJ  (合作)
影响因子:3.393 (2012)

  • biogenesis 生源说
  • demonstrated 探明的储量
  • aging 老化
  • protein 蛋白质
  • mitochondria 线粒体
  • acetylation 乙酰化
  • observed 观察到的
  • exhibit 展出
  • alteration 蚀变
  • nitration 硝化