Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis.
作者: Zheng HuYun-Xin FuAnthony J GreenbergChung-I WuWeiwei Zhai
刊名: PLoS Genetics, 2017, Vol.9 (2)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pgen.1003326
原始语种摘要: In multi-cellular organisms, tissue homeostasis is maintained by an exquisite balance between stem cell proliferation and differentiation. This equilibrium can be achieved either at the single cell level (a.k.a. cell asymmetry), where stem cells follow strict asymmetric divisions, or the population level (a.k.a. population asymmetry), where gains and losses in individual stem cell lineages are randomly distributed, but the net effect is homeostasis. In the mature mouse intestinal crypt, previous evidence has revealed a pattern of population asymmetry through predominantly symmetric divisions of stem cells. In this work, using population genetic theory together with previously published crypt single-cell data obtained at different mouse life stages, we reveal a strikingly dynamic pattern...
全文获取路径: DOAJ  (合作)
影响因子:8.517 (2012)

  • level 水准
  • control 控制
  • population 母体
  • homeostasis 体内平衡
  • previous 先前的
  • asymmetry 非对称
  • trade 买卖
  • dependent 从属的
  • regulations 规则
  • asymmetric 不对称的