Defective DNA repair mechanisms in prostate cancer: impact of olaparib
作者: De Felice FTombolini VMarampon FMusella AMarchetti C
刊名: Drug Design, Development and Therapy, 2017, Vol.Volume11 , pp.547-552
来源数据库: Directory of Open Access Journals
关键词: Prostate cancerMetastatic diseaseCastration-resistantBRCADNA-repairPARPOlaparib.
原始语种摘要: Francesca De Felice,1 Vincenzo Tombolini,1 Francesco Marampon,2 Angela Musella,3 Claudia Marchetti3 1Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, 2Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, 3Department of Gynecological and Obstetrical Sciences and Urological Sciences, “Sapienza” University of Rome, Rome, Italy Abstract: The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition and...
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影响因子:3.486 (2012)

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关键词翻译
关键词翻译
  • prostate 前列腺
  • repair 修理
  • castration 去雄
  • cancer 癌症
  • resistant 耐久的
  • breast 胸部
  • aggressiveness 侵蚀性
  • dramatically 戏剧性地
  • predisposition 素质
  • Aquila 天鹰星座