Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition
作者: Ling GZhang TZhang PSun JHe Z
刊名: International Journal of Nanomedicine, 2016, Vol.Volume 11 , pp.4077-4091
来源数据库: Directory of Open Access Journals
关键词: Mitoxantrone hydrochlorideThree-in-one multifunctional lipid-GcNa nanocarriers (TMLGNs)Sodium glycocholateMultidrug resistanceBreast cancer resistance protein (BCRP)B-cell lymphoma (Bcl-2)
原始语种摘要: Guixia Ling,1 Tianhong Zhang,2 Peng Zhang,2 Jin Sun,1 Zhonggui He1 1Department of Pharmaceutics, 2Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China Abstract: Multidrug resistance (MDR) is a severe obstacle to successful chemotherapy due to its complicated nature that involves multiple mechanisms, such as drug efflux by transporters (P-glycoprotein and breast cancer resistance protein, BCRP) and anti-apoptotic defense (B-cell lymphoma, Bcl-2). To synergistically and completely reverse MDR by simultaneous inhibition of pump and non-pump cellular resistance, three-in-one multifunctional lipid-sodium glycocholate (GcNa) nanocarriers (TMLGNs) have been designed for controlled co-delivery of water-soluble cationic...
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影响因子:3.463 (2012)

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关键词翻译
关键词翻译
  •  蛋白质
  • hydrochloride 盐酸盐
  • glycocholate 甘胆酸盐
  • mitoxantrone 米托蒽醌
  • lipid 脂质
  • resistance 抵抗
  • inhibition 抑制
  • simultaneous 同时的
  • lymphoma 淋巴瘤
  • protein 蛋白质
  • efflux 蛋白质