Growth Arrest-Specific 6 Protein in Patients with Sjögren Syndrome: Determination of the Plasma Level and Expression in the Labial Salivary Gland.
作者: Chen-Hung ChenHsiang-Cheng ChenChi-Ching ChangYi-Jen PengChien-Hsing LeeYi-Shing ShiehYi-Jen HungYuh-Feng Lin
刊名: PLoS ONE, 2017, Vol.10 (10)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0139955
原始语种摘要: Growth arrest-specific protein 6 (Gas6) is a vitamin K-dependent protein expressed by endothelial cells and leukocytes that are involved in cell survival, migration, and proliferation in response to inflammatory processes. The aim of this study was to assess the implications of Gas6 in Sjögren syndrome (SS) and its expression in the labial salivary gland.A total of 254 adults, including 159 with primary Sjögren syndrome (pSS), 34 with secondary Sjögren syndrome (sSS), and 61 normal controls, were recruited. Plasma Gas6 concentrations were determined, and Gas6 expressions in labial salivary gland (LSG) tissues from controls and pSS and sSS patients were also evaluated. Plasma Gas6 concentrations were significantly lower among patients with pSS than normal controls (13.5 ± 8.6 vs. 19.9 ±...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • salivary 唾液的
  • gland 
  • significantly 较大地
  • controls 控制机构
  • concentrations 浓聚物
  • protein 蛋白质
  • labial 唇的
  • survival 生存
  • expression 表示
  • normal 法线