A meta-analysis of anti-vascular endothelial growth factor remedy for macular edema secondary to central retinal vein occlusion.
作者: Peirong HuangWenquan NiuZhentian NiRenzuo WangXiaodong Sun
刊名: PLoS ONE, 2017, Vol.8 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0082454
原始语种摘要: BACKGROUND: Central retinal vein occlusion (CRVO) associates with severe vision outcome and no proven beneficial treatment. Our meta-analysis intended to appraise the efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) agents in macular edema (ME) following CRVO. METHODS: Data were collected and analyzed by Review Manager 5.2.1. We employed a random-effects model to eliminate between-study heterogeneity. Nfs (called fail-safe number) was calculated to evaluate the publication bias. RESULTS: We included 5 trials consisting 323 cases and 281 controls. Primary outcomes showed that overall comparison of anti-VEGF agents with placebo control yielded a 374% and 136% increased tendency for a gain of 15 letters or more on Early Treatment Diabetic Retinopathy Study (ETDRS)...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • remedy 疗法
  • control 控制
  • retinal 视黄醛
  • analysis 分析
  • occlusion 锢囚
  • factor 因素
  • growth 生长
  • macular 具斑点的
  • appraise 评价
  • central 中心的