Pro-inflammatory profile of preeclamptic placental mesenchymal stromal cells: new insights into the etiopathogenesis of preeclampsia.
作者: Alessandro RolfoDomenica GiuffridaAnna Maria NuzzoDaniele PierobonSimona CardaropoliEttore PiccoliMirella GiovarelliTullia Todros
刊名: PLoS ONE, 2017, Vol.8 (3)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0059403
原始语种摘要: UNLABELLED: The objective of the present study was to evaluate whether placental mesenchymal stromal cells (PDMSCs) derived from normal and preeclamptic (PE) chorionic villous tissue presented differences in their cytokines expression profiles. Moreover, we investigated the effects of conditioned media from normal and PE-PDMSCs on the expression of pro-inflammatory Macrophage migration Inhibitory Factor (MIF), Vascular Endothelial Growth Factor (VEGF), soluble FMS-like tyrosine kinase-1 (sFlt-1) and free β-human Chorionic Gonadotropin (βhCG) by normal term villous explants. This information will help to understand whether anomalies in PE-PDMSCs could cause or contribute to the anomalies typical of preeclampsia. METHODS: Chorionic villous PDMSCs were isolated from severe preeclamptic (n =...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • preeclampsia 子痫前期
  • placental 胎盘的
  • mesenchymal 间叶细胞的
  • inflammatory 激怒的
  • villous 具长柔毛的
  • profile 纵断图
  • cytokines 细胞浆移动
  • protein 蛋白质
  • chorionic 绒膜的
  • stromal 基质的