Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway
作者: Zhang HHan DLv TLiu KYang YXu XChen Y
刊名: Drug Design, Development and Therapy, 2019, Vol.Volume 13 , pp.2153-2167
来源数据库: Directory of Open Access Journals
关键词: LeukemiaMulti-drug resistanceNecrosisApoptosisMyristoyl-CM4
原始语种摘要: Huidan Zhang,* Dongju Han,* Tongtong Lv, Kehang Liu, Yunqing Yang, Xixi Xu, Yuqing ChenDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People’s Republic of China*These authors contributed equally to this workPurpose: There is an urgent need for the development of novel, effective, and less toxic drugs to treat leukemia. Antimicrobial peptides (AMPs) have received much more attention as alternative chemotherapeutic agents. This study aimed to examined the cytotoxicity of a novel AMP myristoly-CM4 against chronic myeloid leukemia cells (K562/MDR) and acute lymphocytic leukemia cells (Jurkat), and further investigated its selectivity to clarify the cytotoxic mechanism.Materials and methods: In this study, the cytotoxicity and selectivity of...
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影响因子:3.486 (2012)

  • leukemia 白血病
  • cells 麻风细胞
  • cytotoxicity 细胞毒性
  • necrosis 坏死
  • selective 选择性的
  • apoptosis 细胞死
  • pathway 轨道
  • treat 处理
  • selectivity 选择性
  • mitochondria 线粒体