Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast.
作者: Matthew NorthVickram J TandonReuben ThomasAlex LoguinovInna GerlovinaAlan E HubbardLuoping ZhangMartyn T SmithChris D Vulpe
刊名: PLoS ONE, 2017, Vol.6 (8)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0024205
原始语种摘要: Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene toxicity difficult. We used a functional genomics approach to identify the genes that modulate the cellular toxicity of three of the phenolic metabolites of benzene, hydroquinone (HQ), catechol (CAT) and 1,2,4-benzenetriol (BT), in the model eukaryote Saccharomyces cerevisiae. Benzene metabolites generate oxidative and cytoskeletal stress, and tolerance requires correct regulation of iron homeostasis and the vacuolar ATPase. We have identified a conserved bZIP transcription factor, Yap3p, as important for a...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • functional 功能的
  • required 必需
  • benzene 
  • yeast 酵母
  • ubiquitous 同时普遍存在的
  • tolerance 耐性
  • vacuolar 析稀胶粒的
  • toxicity 毒性
  • hydroquinone 氢醌
  • encode 编成密码