The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status
作者: Tulay AkmanIlhan OztopYasemin BaskinIlkay Tugba UnekNecla DemirHulya EllidokuzAhmet Ugur Yilmaz
刊名: Journal of Cancer Research and Therapeutics, 2016, Vol.12 (1), pp.96-102
来源数据库: Directory of Open Access Journals
DOI: 10.4103/0973-1482.148684
关键词: Clinicopathological propertiesKRASMetastatic colorectal cancerPrognosis
原始语种摘要: Background: KRAS mutations have a significant role in the consecutive activation of RAS.RAF.MEK.ERK pathway in colorectal cancer.Approximately 30.35% of sporadic colorectal cancers have KRAS mutation. While the predictive role of KRAS is commonly accepted at the present time, its prognostic role and association with different clinical and histopathological properties are currently unclear and inconsistent. The intent of this study, has been to evaluate the associations between KRAS gene mutations and clinicopathological features and survival times in Turkish colorectal cancer patients.Materials and Methods: In this study, the file records of 115 metastatic colorectal cancer patients who applied to the Department of Medical Oncology between 2000 and 2011 were monitored; data on...
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影响因子:0.761 (2012)

  • survival 生存
  • colorectal 结肠直肠的
  • association 联合
  • mutation 变种
  • status 状态
  • cancer 癌症
  • features 特征
  • prognosis 预报
  • unclear 不清楚的
  • intent 意图