The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate
作者: Po-Li WeiShih-Hsin TuHsiu-Man LienLi-Ching ChenChing-Shyang ChenChih-Hsiung WuChing-Shui HuangHui-Wen ChangChien-Hsi ChangHow TsengYuan-Soon Ho
刊名: Journal of Cancer Research and Therapeutics, 2012, Vol.8 (4), pp.532-536
来源数据库: Directory of Open Access Journals
DOI: 10.4103/0973-1482.106529
关键词: AntitumorApioleSY-1Colon tumorCOLO 205
原始语种摘要: Context: The compound 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) has been isolated from several different plant species, including Petroselinum sativum. Our recent study found that apiole is a chemical derivative of 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1), which has been isolated from dried Antrodia camphorata (AC ) fruiting bodies, a traditional Chinese medicine with antitumor properties.Aims: Our previous in vitro study demonstrated that apiole inhibits the growth of human colon (COLO 205) cancer cells through the arrest of the cell cycle in G0/G1 phase. The in vivo antitumor effects of apiole were evaluated in this study.Setting and Design: Apiole was administered to mice at 1-30 mg/kg body weight through intraperitoneal (I.P.) injection three times per week...
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影响因子:0.761 (2012)

  • apiole 芹菜脑
  • benzodioxole 苯并二恶茂
  • dimethoxy 二甲氧基
  • antitumor 抗癌的
  • camphorate 使...与樟脑化合
  • derivative 衍生物
  • fruiting 结实
  • methyl 甲基
  • effects 海员自身物品
  • cells 麻风细胞