Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans.
作者: Jatinder S SanghaXiaoli SunOwen S D WallyKaibin ZhangXiuhong JiZhimin WangYanwen WangJeffrey ZidichouskiBalakrishnan PrithivirajJunzeng Zhang
刊名: PLoS ONE, 2017, Vol.7 (8)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0043990
原始语种摘要: Liuwei Dihuang (LWDH), a classic Chinese medicinal formula, has been used to improve or restore declined functions related to aging and geriatric diseases, such as impaired mobility, vision, hearing, cognition and memory. Here, we report on the effect and possible mechanisms of LWDH mediated protection of β-amyloid (Aβ) induced paralysis in Caenorhabditis elegans using ethanol extract (LWDH-EE) and water extract (LWDH-WE). Chemical profiling and quantitative analysis revealed the presence of different levels of bioactive components in these extracts. LWDH-WE was rich in polar components such as monosaccharide dimers and trimers, whereas LWDH-EE was enriched in terms of phenolic compounds such as gallic acid and paeonol. In vitro studies revealed higher DPPH radical scavenging activity for...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • amyloid 淀粉状朊
  • expression 表示
  • observed 观察到的
  • whereas 鉴于
  • reporter 报告生成程序
  • related 有关的
  • medicinal 医学的
  • induced 感应的
  • together 共同
  • although 虽然