Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.
作者: Chang-Yun WangNicole J. de VoogdZhi-Gang ShePei-Yuan QianYi-Yan ChenXiu-Mei FuCai-Juan ZhengYing XuChang-Lun ShaoRui-Yun YangDan Li
刊名: Marine Drugs, 2012, Vol.10 (1), pp.234-241
来源数据库: Directory of Open Access Journals
DOI: 10.3390/md10010234
关键词: Bisabolane-type sesquiterpenoidAntibacterialSponge-derived fungusAspergillus sp.
原始语种摘要: Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (−)-sydonol (2), (−)-sydonic acid (3), and (−)-5-(hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Four of them (1–4) are optically active compounds. Their structures and absolute configurations were elucidated by using NMR spectroscopic techniques and mass spectrometric analysis, and by comparing their optical rotations with those related known analogues. Compounds 1–5 showed selective antibacterial activity against eight bacterial strains with the MIC (minimum inhibiting...
全文获取路径: DOAJ  (合作)
影响因子:3.978 (2012)

  • spectrometric 光谱测定的
  • metabolite 蚀变粗玻岩
  • antibacterial 抗细菌的
  • fungus 真菌
  • cytotoxic 细胞毒素的
  • inhibiting 抑制
  • against 反对
  • derived 导生的
  • bisabolane 没药烷
  • inhibitory 禁止的