The association of four common polymorphisms from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity: a meta-analysis.
作者: Zhiyuan WengXiaobo LiYuqiong LiJinxiu LinFeng PengWenquan Niu
刊名: PLoS ONE, 2017, Vol.8 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0078093
原始语种摘要: OBJECTIVE: Evidence is mounting suggesting that a strong genetic component underlies aspirin insensitivity. To generate more information, we aimed to evaluate the association of four common polymorphisms (rs3842787, rs20417, rs201184269, rs1126643) from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity via a meta-analysis. METHODS AND RESULTS: In total, there were 4 (353/595), 6 (344/698), 10 (588/878) and 7 (209/676) articles (patients/controls) qualified for rs3842787, rs20417, rs20118426 and rs1126643, respectively. The data were extracted in duplicate and analyzed by STATA software (Version 11.2). The risk estimate was expressed as odds ratio (OR) and 95% confidence interval (95% CI). Analyses of the full data set indicated significant associations of...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • aspirin 阿司匹林
  • insensitivity 不灵敏度
  • candidate 选择物
  • association 联合
  • analysis 分析
  • articles 用品
  • estimate 估计
  • observed 观察到的
  • confidence 信用
  • especially 特别地