An interactive association of advanced glycation end-product receptor gene four common polymorphisms with coronary artery disease in northeastern Han Chinese.
作者: Xiaohong YuJun LiuHao ZhuYunlong XiaLianjun GaoZhen LiNan JiaWeifeng ShenYanzong YangWenquan Niu
刊名: PLoS ONE, 2017, Vol.8 (10)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0076966
原始语种摘要: BACKGROUND: Growing evidence indicates that advanced glycation end-product receptor (RAGE) might play a contributory role in the pathogenesis of coronary artery disease (CAD). To shed some light from a genetic perspective, we sought to investigate the interactive association of RAGE gene four common polymorphisms (rs1800625 or T-429C, rs1800624 or T-374A, rs2070600 or Gly82Ser, and rs184003 or G1704A) with the risk of developing CAD in a large northeastern Han Chinese population. METHODOLOGY/PRINCIPAL FINDINGS: This was a hospital-based case-control study incorporating 1142 patients diagnosed with CAD and 1106 age- and gender-matched controls. All individuals were angiographically confirmed. Risk estimates were expressed as odds ratio (OR) and 95% confidence interval (CI). Overall there...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • northeastern 来自东北的
  • interactive 相互作用的
  • multifactor 多因素
  • product 产物
  • advanced 先进的
  • Chinese 汉语
  • common 普通
  • coronary 冠状的
  • evidence 
  • control 控制