Chaperonin-Containing t-Complex Protein-1 Subunit β as a Possible Biomarker for the Phase of Glomerular Hyperfiltration of Diabetic Nephropathy
作者: Chung-Ze WuLi-Chien ChangYuh-Feng LinYi-Jen HungDee PeiJin-Shuen Chen
作者单位: 1raduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
2School of Pharmacy, National Defense Medical Center, Taipei, Taiwan
3Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
4Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
5Division of Endocrinology and Metabolism, Department of Internal Medicine, Cardi
刊名: Disease Markers, 2015, Vol.2015
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2015/548101
原始语种摘要: In cell model, we discovered the association between chaperonin-containing t-complex polypeptide 1 subunit β (TCP-1β) and early diabetic nephropathy (DN). In this study, we further explored the relationships between TCP-1β and type 2 diabetic mellitus (DM). To mimic the clinical hyperfiltration state, a type 2 DM mice model was established by feeding a high-fat diet in combination with treatment of streptozotocin and nicotinamide. Blood and urine were collected to determine creatinine clearance (Ccr), and kidney tissues were harvested for evaluation of TCP-1β expression by immunohistochemistry and Western blot. Meanwhile, clinical subjects of healthy controls and type 2 DM were recruited to strengthen the evidence with urine TCP-1β. Results showed that Ccr and the expression of TCP-1β in...
全文获取路径: DOAJ  (合作)
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影响因子:2.14 (2012)

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关键词翻译
关键词翻译
  • nephropathy 肾病
  • streptozotocin 链脲佐菌素
  • hyperglycemia 高血糖
  • diabetic 糖尿病患者
  • glomerular 肾小球病
  • creatinine 肌酸酐
  • urine 尿
  • nicotinamide 烟酰胺
  • kidney 肾脏
  • clearance 间隙