Evolution and Distribution of Saxitoxin Biosynthesis in Dinoflagellates
作者: Kjetill S. JakobsenShauna A. MurrayRussell J. S. OrrAnke Stüken
刊名: Marine Drugs, 2013, Vol.11 (8), pp.2814-2828
来源数据库: Directory of Open Access Journals
DOI: 10.3390/md11082814
关键词: CyanobacteriaDinoflagellatesHarmful algal blooms (HABs)Horizontal gene transfer (HGT)PhylogenyParalytic shellfish poisoning (PSP)Paralytic shellfish toxin (PST)SaxitoxinSTX
原始语种摘要: Numerous species of marine dinoflagellates synthesize the potent environmental neurotoxic alkaloid, saxitoxin, the agent of the human illness, paralytic shellfish poisoning. In addition, certain freshwater species of cyanobacteria also synthesize the same toxic compound, with the biosynthetic pathway and genes responsible being recently reported. Three theories have been postulated to explain the origin of saxitoxin in dinoflagellates: The production of saxitoxin by co-cultured bacteria rather than the dinoflagellates themselves, convergent evolution within both dinoflagellates and bacteria and horizontal gene transfer between dinoflagellates and bacteria. The discovery of cyanobacterial saxitoxin homologs in dinoflagellates has enabled us for the first time to evaluate these theories....
全文获取路径: DOAJ  (合作)
影响因子:3.978 (2012)

  • saxitoxin 石房蛤毒素
  • shellfish 
  • paralytic 麻痹的
  • algal 藻类的
  • cyanobacteria 蓝藻细菌
  • evolutionary 进化
  • neurotoxin 神经毒素
  • neurotoxic 神经中毒的
  • potent 强大的
  • biosynthetic 生物合成