SNPs in the TGF-β signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.
作者: Qianxia LiHuanlei WuBei ChenGuangyuan HuLiu HuangKai QinYu ChenXianglin YuanZhongxing Liao
刊名: PLoS ONE, 2017, Vol.7 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0051713
原始语种摘要: PURPOSE: Brain metastasis (BM) from non-small cell lung cancer (NSCLC) is relatively common, but identifying which patients will develop brain metastasis has been problematic. We hypothesized that genotype variants in the TGF-β signaling pathway could be a predictive biomarker of brain metastasis. PATIENTS AND METHODS: We genotyped 33 SNPs from 13 genes in the TGF-β signaling pathway and evaluated their associations with brain metastasis risk by using DNA from blood samples from 161 patients with NSCLC. Kaplan-Meier analysis was used to assess brain metastasis risk; Cox hazard analyses were used to evaluate the effects of various patient and disease characteristics on the risk of brain metastasis. RESULTS: The median age of the 116 men and 45 women in the study was 58 years; 62 (39%) had...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • metastasis 同质蜕变
  • brain 
  • pathway 轨道
  • associated 相关的
  • signaling 发信号
  • cancer 癌症
  • increased 增加
  • combined 组合
  • predictive 预言
  • significantly 较大地