Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model
作者: Jessica Ruivo MaximinoGabriela Pintar de OliveiraChrystian Junqueira AlvesGerson eChadi
作者单位: 1University of Sao Paulo School of Medicine
刊名: Frontiers in Cellular Neuroscience, 2014, Vol.8
来源数据库: Directory of Open Access Journals
DOI: 10.3389/fncel.2014.00148
关键词: Sciatic NerveSpinal CordALSSOD1G93APre-symptomaticKif1b microarray
原始语种摘要: Early molecular events related to cytoskeleton are poorly described in Amyotrophic Lateral Sclerosis (ALS), especially in the Schwann cell (SC), which offers strong trophic support to motor neurons. DAVID tool identified cytoskeleton-related genes by employing the Cellular Component Ontology (CCO) in a large gene profiling of lumbar spinal cord and sciatic nerve of presymptomatic SOD1G93A mice. One and five CCO terms related to cytoskeleton were described from the spinal cord deregulated genes of 40 days (actin cytoskeleton) and 80 days (microtubule cytoskeleton, cytoskeleton part, actin cytoskeleton, neurofilament cytoskeleton and cytoskeleton) old transgene mice, respectively. Also, four terms were depicted from the deregulated genes of sciatic nerve of 60 days old transgenes (actin...
全文获取路径: DOAJ  (合作)
影响因子:4.469 (2012)

  • sciatic 坐骨的
  • nerve 叶脉
  • cytoskeleton 细胞骨架
  • spinal 脊柱的
  • SOD Superintendent Of Documents
  • ALS Accumulator Left Shift
  • expression 表示
  • neurofilament 神经丝
  • findings 结论
  • related 有关的