Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway
作者: W. RungratanawanichG. AbateM. M. SerafiniM. GuarientiM. CatanzaroM. MarzianoM. MemoC. LanniD. Uberti
作者单位: 1epartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
2Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
3Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy
4Department of Drug Sciences, University of Pavia, Pavia, Italy
5Department of Molecular and
刊名: Oxidative Medicine and Cellular Longevity, 2018, Vol.2018
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2018/2987249
原始语种摘要: γ-Oryzanol (ORY) is well known for its antioxidant potential. However, the mechanism by which ORY exerts its antioxidant effect is still unclear. In this paper, the antioxidant properties of ORY were investigated for its potential effects as a reactive oxygen and nitrogen species (ROS/RNS) scavenger and in activating antioxidant-promoting intracellular pathways utilizing the human embryonic kidney cells (HEK-293). The 24 h ORY exposure significantly prevented hydrogen peroxide- (H2O2-) induced ROS/RNS production at 3 h, and this effect was sustained for at least 24 h. ORY pretreatment also enhanced the activity of antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPX). Interestingly, ORY induced the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear...
全文获取路径: DOAJ  (合作)
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影响因子:3.393 (2012)

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关键词翻译
关键词翻译
  • antioxidant 抗氧化剂
  • pretreatment 预处理
  • scavenger 食腐动物
  • synthetase 合成酶
  • induced 感应的
  • effect 效应
  • superoxide 过氧化物
  • potential 
  • translocation 移位
  • glutathione 谷胱甘肽