Colonic inflammation in mice is improved by cigarette smoke through iNKT cells recruitment.
作者: Muriel MontbarbonMuriel PichavantAudrey LangloisEdmone ErdualFrançois MaggiottoChristel NeutThierry MallevaeySébastien DharancyLaurent DubuquoyFrançois TrotteinAntoine CortotPierre DesreumauxPhilippe GossetBenjamin Bertin
刊名: PLoS ONE, 2017, Vol.8 (4)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0062208
原始语种摘要: Cigarette smoke (CS) protects against intestinal inflammation during ulcerative colitis. Immunoregulatory mechanisms sustaining this effect remain unknown. The aim of this study was to assess the effects of CS on experimental colitis and to characterize the intestinal inflammatory response at the cellular and molecular levels. Using the InExpose® System, a smoking device accurately reproducing human smoking habit, we pre-exposed C57BL/6 mice for 2 weeks to CS, and then we induced colitis by administration of dextran sodium sulfate (DSS). This system allowed us to demonstrate that CS exposure improved colonic inflammation (significant decrease in clinical score, body weight loss and weight/length colonic ratio). This improvement was associated with a significant decrease in colonic...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • inflammation 炎症
  • recruitment 补充
  • cells 麻风细胞
  • cigarette 香烟
  • colitis 大肠炎
  • responsiveness 应答性
  • colonic 结肠的
  • smoke 灰云
  • exposure 暴露
  • ulcerative 使...形成溃疡的