Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations
作者: Codenotti SMansoury WPinardi LMonti EMarampon FFanzani A
刊名: OncoTargets and Therapy, 2019, Vol.Volume 12 , pp.5257-5268
来源数据库: Directory of Open Access Journals
关键词: LiposarcomaTransgenic animal modelXenograft.
原始语种摘要: Silvia Codenotti,1 Walaa Mansoury,1 Luca Pinardi,1 Eugenio Monti,1 Francesco Marampon,2 Alessandro Fanzani11Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; 2Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, ItalyAbstract: Liposarcoma is a malignant neoplasm of fat tissue. Well-differentiated and dedifferentiated liposarcoma (WDL/DDL) represent the two most clinically observed histotypes occurring in middle-aged to older adults, particularly within the retroperitoneum or extremities. WDL/DDL are thought to represent the broad spectrum of one disease, as they are both associated with the amplification in the chromosomal 12q13-15 region that causes MDM2 and CDK4 overexpression, the most useful predictor for...
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影响因子:2.073 (2012)

  • liposarcoma 脂肉瘤
  • differentiated 区别
  • animal 动物的
  • well 
  • observed 观察到的
  • represent 代表
  • genetic 遗传的
  • region 地域
  • facilitate 简化
  • additional 追加的