Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity
作者: Khan MWZhao PKhan ARaza FRaza SMSarfraz MChen YLi MYang TMa XXiang G
刊名: International Journal of Nanomedicine, 2019, Vol.Volume 14 , pp.3753-3771
来源数据库: Directory of Open Access Journals
关键词: Combination therapyCisplatinOleanolic acidHepatocellular carcinomaHepatotoxicity.
原始语种摘要: Muhammad Waseem Khan,1 Pengxuan Zhao,1 Asifullah Khan,2 Faisal Raza,2 Shahid Masood Raza,1 Muhammad Sarfraz,3 Yan Chen,1 Minsi Li,1 Tan Yang,1 Xiang Ma,1 Guangya Xiang11School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2State Key Laboratory of Natural Medicines and Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, People’s Republic of China; 3School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475001/475004, People’s Republic of ChinaBackground: Cisplatin (CDDP), a widely used chemotherapeutic agent against hepatocellular carcinoma (HCC), faces severe resistance and hepatotoxicity problems which can be alleviated through combination therapy.Purpose: The...
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影响因子:3.463 (2012)

  • hepatocellular 肝细胞性的
  • cisplatin 顺氯氨铂
  • carcinoma 癌症
  • hepatotoxicity 肝毒性
  • apoptosis 细胞死
  • enhanced 增强
  • carbonate 碳酸盐
  • calcium 
  • microemulsion 微型乳剂
  • against 反对