Anna Dmoszyńska, Adam Kłos, Beata Piechnik, Krzysztof Giannopoulos, Paulina Wdowiak, Magdalena Wasiak, Iwona Hus, Sebastian Radej, Jacek Tabarkiewicz, Jacek Rolinski
||Folia Histochemica et Cytobiologica, 2008, Vol.46 (2), pp.165-170
||Directory of Open Access Journals
We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.