Post-transcriptional regulator Hfq binds catalase HPII: crystal structure of the complex.
作者: Koji YonekuraMasahiro WatanabeYuko KageyamaKunio HirataMasaki YamamotoSaori Maki-Yonekura
刊名: PLoS ONE, 2018, Vol.8 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0078216
原始语种摘要: We report a crystal structure of Hfq and catalase HPII from Escherichia coli. The post-transcriptional regulator Hfq plays a key role in the survival of bacteria under stress. A small non-coding RNA (sRNA) DsrA is required for translation of the stationary phase sigma factor RpoS, which is the central regulator of the general stress response. Hfq facilitates efficient translation of rpoS mRNA, which encodes RpoS. Hfq helps in the function of other specific proteins involved in RNA processing, indicating its versatility in the cell. However, structural information regarding its interactions with partners is missing. Here we obtained crystals of Hfq and HPII complexes from cell lysates following attempts to overexpress a foreign membrane protein. HPII is one of two catalases in E. coli and...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • catalase 过氧化氢酶
  • hexamer 六聚物
  • crystal 晶体
  • holoenzyme 全酶
  • regulator 第器
  • proteins 蛋白质
  • small 小的
  • known 己知
  • required 必需