Co-loading antioxidant N-acetylcysteine attenuates cytotoxicity of iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes
作者: Shen YGong SLi JWang YZhang XZheng HZhang QYou JHuang ZChen Y
刊名: International Journal of Nanomedicine, 2019, Vol.Volume 14 , pp.6103-6115
来源数据库: Directory of Open Access Journals
关键词: N-acetylcysteine (NAC)Iron oxide nanoparticlesOxidative stressCardiomyocytesHypoxia-Reoxygenation
原始语种摘要: Yunli Shen,1,* Shiyu Gong,1,* Jiming Li,1,* Yunkai Wang,1 Xumin Zhang,1 Hao Zheng,1 Qi Zhang,1 Jieyun You,1 Zheyong Huang,2 Yihan Chen11Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China; 2Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, People’s Republic of China*These authors contributed equally to this workPurpose: Myocardial delivery of magnetic iron oxide nanoparticles (MNPs) might produce iron overload-induced myocardial injury, and the oxidative stress was regarded as the main mechanism. Therefore, we speculated antioxidant modification might be a reasonable strategy to mitigate the toxicity of MNPs.Methods and results: Antioxidant N-acetylcysteine...
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影响因子:3.463 (2012)

  • acetylcysteine 乙酰半胱胺酸
  • reoxygenation 再氧化
  • hypoxia 氧过少
  • antioxidant 抗氧化剂
  • cytotoxicity 细胞毒性
  • oxide 氧化物
  • induced 感应的
  • oxidative 氧化的
  • mitigate 减轻
  • stress 应力