Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production
作者: Lingbo KongBiao WangXiaobin YangHua GuoKe ZhangZiqi ZhuJijun LiuDingjun Hao
刊名: Cellular Physiology and Biochemistry, 2017, Vol.43 (4), pp.1-1
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000481874
关键词: Picrasma QuassioidesReactive oxygen species (ROS)Osteoclastogenesis
原始语种摘要: Background/Aims: Osteoporosis is a metabolic bone disorder that tortures about millions of people worldwide. Recent study demonstrated agents derived from picrasma quassioides is a promising drug for targets multiple signaling pathways. However its potential in treatment of bone loss has not been fully understood. Methods: The bone marrow macrophages (BMMs) were cultured and induced with M-CSF and RANKL followed by picrasidine I (PI) treatment. Then the effects of PI on osteoclast formation were evaluated by counting tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells. Moreover, effects of PI on bone resorption activity of mature osteoclast were studied through bone resorption pit counting and actin ring structure analysis. Further, the involved potential signaling...
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  • osteoclast 破骨细胞
  • resorption 再吸收
  • ROS Read Only Storage
  • osteoblast 成骨细胞
  • demonstrated 探明的储量
  • induced 感应的
  • potential 
  • inhibiting 抑制
  • attenuating 衰减的
  • inflammation 炎症