Astrovirus infection in hospitalized infants with severe combined immunodeficiency after allogeneic hematopoietic stem cell transplantation.
作者: Werner WunderliAstrid MeerbachTayfun GüngörChristoph BergerOliver GreinerRosmarie CaduffAlexandra TrkolaWalter BossartDaniel GerlachManuel SchiblerSamuel CordeyThomas Alexander McKeeSandra Van BelleLaurent KaiserCaroline Tapparel
刊名: PLoS ONE, 2017, Vol.6 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0027483
原始语种摘要: Infants with severe primary combined immunodeficiency (SCID) and children post-allogeneic hematopoietic stem cell transplantation (HSCT) are extremely susceptible to unusual infections. The lack of generic tools to detect disease-causing viruses among more than 200 potential human viral pathogens represents a major challenge to clinicians and virologists. We investigated retrospectively the causes of a fatal disseminated viral infection with meningoencephalitis in an infant with gamma C-SCID and of chronic gastroenteritis in 2 other infants admitted for HSCT during the same time period. Analysis was undertaken by combining cell culture, electron microscopy and sequence-independent single primer amplification (SISPA) techniques. Caco-2 cells inoculated with fecal samples developed a...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • hematopoietic 补血药
  • allogeneic 他生的
  • infection 感染
  • combined 组合
  • severe 严滥
  • detected 找到
  • viral 病毒性的
  • disseminated 浸染的
  • transcription 地名转写
  • potential